Asymmetric bi-soft segment poly(ester urethane urea) (PEUU) membranes containing polycaprolactone (PCL) as a second soft\r\nsegment are synthesized with PCL-diol ranging from 0% to 15% (w/w). Bulk and surface characteristics of the PEUU membranes\r\nwere investigated by scanning electron microscopy (SEM), static water contact angles, and surface streaming potentials and were\r\ncorrelated to hemocompatibility properties, namely, hemolysis and thrombosis degrees. SEM analysis reveals PEUU membranes\r\nwith asymmetric cross-sections and top dense surfaces with distinct morphologies. The increase in PCL-diol content yields PEUU\r\nmembranes with blood-contacting surfaces that are smoother, more hydrophilic, and with higher maximum zeta potentials. The\r\nresults obtained in this work give no evidence of a correlation between hydrophilicity/zeta potentials and the hemolysis/thrombosis\r\ndegree of blood-contacting surfaces of the PEUU membranes. In contrast, other hemocompatibility aspects reveal that the more\r\nhydrophilic membranes are associated with lower platelet deposition and inhibition of extreme states of platelet activation.
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